A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name hsa-miR-124
ncRNA Category miRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods transfection, qRT-PCR, Western blot, Phalloidin staining, immunocytochemistry, luciferase reporter assay
Expression pattern down-regulated
Functional description This study describes the regulation of EMT in RPE cells by TGF-β1/miR-124/RHOG signaling and suggests that the supplement of miR-124 exogenously would be a valuable therapeutic approach for the prevention or treatment of proliferative vitreoretinopathy.
PubMed ID 26746014
Year 2016
Title MicroRNA-124 Controls Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in the Retinal Pigment Epithelium by Targeting RHOG.
Drug-related ncRNA NO

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