A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name MITF siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human fetal RPE cells, human fetal choroidal fibroblast cells
Methods siRNA transfection, Western blot, immunofluorescence
Expression pattern associated
Functional description Microphthalmia-associated transcription factor (MITF) is a key regulator of RPE differentiation that was also down-regulated in dedifferentiated hfRPE cells. MITF knockdown decreased miR-204/211 expression and caused hfRPE dedifferentiation. Significantly, co-transfection of MITF siRNA with pre-miR-204/211 rescued RPE phenotype.
PubMed ID 22523078
Year 2012
Title Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression.
Drug-related ncRNA NO

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