A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name PMP22 siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods siRNA transfection, Western blot, flow cytometry
Expression pattern associated
Functional description Integrin-mediated collagen gel contraction by ARPE-19 is an in vitro model for proliferative vitreoretinopathy (PVR). PMP22 differentially regulates collagen gel contraction in the ARPE-19 cell line. The decrease in gel contraction by the ARPE-19/PMP22 cells was partially reversed through either PMP22 siRNA or by blockade of AKT.
PubMed ID 21421883
Year 2011
Title Rewiring integrin-mediated signaling and cellular response with the peripheral myelin protein 22 and epithelial membrane protein 2 components of the tetraspan web.
Drug-related ncRNA NO

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