A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name hsa-miR-34a
ncRNA Category miRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods immunofluorescence staining, qPCR, WST-1 assay, TUNEL assay, transwell assay, in vitro scratch assay, Western blot
Expression pattern down-regulated
Functional description MicroRNA-34a can inhibit the proliferation and migration of RPE cells through downregulation of its targets c-Met and other cell cycle-related molecules.
PubMed ID 23970470
Year 2013
Title Inhibitory effect of microRNA-34a on retinal pigment epithelial cell proliferation and migration.
Drug-related ncRNA NO

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