A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name mTOR siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Oryctolagus cuniculus
Tissues/Cell_line retinas
Methods siRNA injection, fundus photography
Expression pattern associated
Functional description Decreasing mTOR expression by about 82% using small interfering RNA resulted in a significant decrease in cell spreading and migration. Whereas retinal detachment occurred in 100% of the control group animals, co-injection of the mTOR specific siRNA substantially reduced the severity and incidence (50%) of retinal detachments.
PubMed ID 18027173
Year 2007
Title siRNA targeting mammalian target of rapamycin (mTOR) attenuates experimental proliferative vitreoretinopathy.
Drug-related ncRNA NO

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