A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name FAK siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods siRNA transfection, flow cytometry, Western blot, adhesion assay
Expression pattern associated
Functional description FAK siRNA transient transfection significantly reduced FAK protein expression by 71% (P=0.02) and concordantly decreased gel contraction (P=0.0001).
PubMed ID 17915217
Year 2007
Title Collagen gel contraction by ARPE-19 cells is mediated by a FAK-Src dependent pathway.
Drug-related ncRNA NO

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