A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name hsa-miR-204
ncRNA Category miRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human fetal RPE cells, human fetal choroidal fibroblast cells
Methods microarray, qRT-PCR, transfection, Western blot, immunofluorescence
Expression pattern down-regulated
Functional description miR-204/211 promote RPE differentiation, suggesting that miR-204/211-based therapeutics may be effective treatments for diseases that involve RPE dedifferentiation such as proliferative vitreoretinopathy.
PubMed ID 22523078
Year 2012
Title Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression.
Drug-related ncRNA NO

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