A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name MALAT1
ncRNA Category lncRNA
ID 378938
Ensembl ENSG00000251562
Synonyms HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO1073, mascRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line epiretinal membranes (ERMs), blood; human RPE cell line ARPE-19
Methods microarray, qRT-PCR, siRNA transfection, MTT assay, Trypan blue staining, scratch wound assay
Expression pattern up-regulated
Functional description Microarray analysis revealed that 78 lncRNAs were abnormally expressed in the epiretinal membranes (ERMs) of PVR patients, including 48 up-regulated and 30 down-regulated lncRNA transcripts. MALAT1 is a potential prognostic indicator and a target for the diagnosis and gene therapy for PVR diseases. In vitro experiments revealed the role of MALAT1 in regulating RPE proliferation and migration.
PubMed ID 26241674
Year 2015
Title Identification and characterization of proliferative retinopathy-related long noncoding RNAs.
Drug-related ncRNA NO

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