A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of primary open-angle glaucoma (POAG)
ncRNA name mmu-miR-34b
ncRNA Category miRNA
Disease name primary open-angle glaucoma (POAG)
Species Mus musculus
Tissues/Cell_line retinal ganglion cell line RGC-5
Methods transfection, cell growth assay, luciferase reporter assay, Western blot, apoptosis assay
Expression pattern associated
Functional description Rs4938723 (especially rs4938723 T > C) SNP could elevate the transcription efficiency of miR-34b promoter and the suppression of TP53, a virtual target of miR-34b. Rs4938723 polymorphism T > C could reduce the incidence of POAG by downregulating TP53 expression, thus leading to suppressed cell apoptosis and enhanced cell proliferation.
PubMed ID 30861198
Year 2019
Title Association between rs4938723 polymorphism and the risk of primary open-angle glaucoma (POAG) in a Chinese population.
Drug-related ncRNA NO

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