| ncRNA name | mmu-miR-34b |
| ncRNA Category | miRNA |
| Disease name | primary open-angle glaucoma (POAG) |
| Species | Mus musculus |
| Tissues/Cell_line | retinal ganglion cell line RGC-5 |
| Methods | transfection, cell growth assay, luciferase reporter assay, Western blot, apoptosis assay |
| Expression pattern | associated |
| Functional description | Rs4938723 (especially rs4938723 T > C) SNP could elevate the transcription efficiency of miR-34b promoter and the suppression of TP53, a virtual target of miR-34b. Rs4938723 polymorphism T > C could reduce the incidence of POAG by downregulating TP53 expression, thus leading to suppressed cell apoptosis and enhanced cell proliferation. |
| PubMed ID | 30861198 |
| Year | 2019 |
| Title | Association between rs4938723 polymorphism and the risk of primary open-angle glaucoma (POAG) in a Chinese population. |
| Drug-related ncRNA | NO |
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