|primary open-angle glaucoma (POAG)
|blood; human embryonic kidney cell line HEK293
|GWAS meta-analyses, Sanger sequencing, transfection, qRT-PCR, luciferase reporter assay
|Of 411 miRNA variants, rs12803915:A/G in the terminal loop of pre-miR-612 and rs2273626:A/C in the seed sequence of miR-4707 were significantly associated with VCDR and cup area (P values < 1.2 × 10-4). The first variant is demonstrated to increase the miR-612 expression.
|A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma.
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