| ncRNA name | hsa-pre-miR-612 |
| ncRNA Category | miRNA |
| Disease name | primary open-angle glaucoma (POAG) |
| Species | Homo sapiens |
| Tissues/Cell_line | blood; human embryonic kidney cell line HEK293 |
| Methods | GWAS meta-analyses, Sanger sequencing, transfection, qRT-PCR, luciferase reporter assay |
| Expression pattern | associated |
| Functional description | Of 411 miRNA variants, rs12803915:A/G in the terminal loop of pre-miR-612 and rs2273626:A/C in the seed sequence of miR-4707 were significantly associated with VCDR and cup area (P values < 1.2 × 10-4). The first variant is demonstrated to increase the miR-612 expression. |
| PubMed ID | 29049738 |
| Year | 2017 |
| Title | A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma. |
| Drug-related ncRNA | NO |
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