A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of primary open-angle glaucoma (POAG)
ncRNA name hsa-pre-miR-612
ncRNA Category miRNA
Disease name primary open-angle glaucoma (POAG)
Species Homo sapiens
Tissues/Cell_line blood; human embryonic kidney cell line HEK293
Methods GWAS meta-analyses, Sanger sequencing, transfection, qRT-PCR, luciferase reporter assay
Expression pattern associated
Functional description Of 411 miRNA variants, rs12803915:A/G in the terminal loop of pre-miR-612 and rs2273626:A/C in the seed sequence of miR-4707 were significantly associated with VCDR and cup area (P values < 1.2 × 10-4). The first variant is demonstrated to increase the miR-612 expression.
PubMed ID 29049738
Year 2017
Title A Genome-Wide Scan for MicroRNA-Related Genetic Variants Associated With Primary Open-Angle Glaucoma.
Drug-related ncRNA NO

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