A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of primary open-angle glaucoma (POAG)
ncRNA name hsa-miR-518d-3p
ncRNA Category miRNA
Disease name primary open-angle glaucoma (POAG)
Species Homo sapiens
Tissues/Cell_line aqueous humor
Methods TaqMan Low-Density PCR Arrays, qPCR
Expression pattern up-regulated
Functional description Significant up-regulation of miR-518d and miR-143, and significant down-regulation of miR-660, was observed in the AH of POAG patients compared with controls. These miRNAs were predicted to reduce cell proliferation and extracellular matrix remodeling, endocytosis, Wnt signaling, ubiquitin-mediated proteolysis, and adherens junction function.
PubMed ID 28586912
Year 2017
Title Comparison of MicroRNA Expression in Aqueous Humor of Normal and Primary Open-Angle Glaucoma Patients Using PCR Arrays: A Pilot Study.
Drug-related ncRNA NO

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