A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of primary open-angle glaucoma (POAG)
ncRNA name Optineurin siRNA
ncRNA Category siRNA
Disease name primary open-angle glaucoma (POAG)
Species Rattus norvegicus
Tissues/Cell_line rat pheochromocytoma cell line PC12
Methods siRNA transfection, Transmission electron microscopy, qRT-PCR, Western blot, MTT assay, flow cytometry, microarray
Expression pattern associated
Functional description SiRNA effectively downregulated optineurin expression in RGC-5 and PC12 stable transfected cells. Optineurin siRNA significantly inhibited cell growth and increased apoptosis in RGC-5 and PC12 cells.
PubMed ID 22194658
Year 2012
Title Effects of optineurin siRNA on apoptotic genes and apoptosis in RGC-5 cells.
Drug-related ncRNA NO

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