|primary open-angle glaucoma (POAG)
|retinal ganglion cell line RGC-5
|siRNA transfection, Transmission electron microscopy, qRT-PCR, Western blot, MTT assay, flow cytometry, microarray
|SiRNA effectively downregulated optineurin expression in RGC-5 and PC12 stable transfected cells. Optineurin siRNA significantly inhibited cell growth and increased apoptosis in RGC-5 and PC12 cells.
|Effects of optineurin siRNA on apoptotic genes and apoptosis in RGC-5 cells.
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