A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of primary open-angle glaucoma (POAG)
ncRNA name HES1 shRNA
ncRNA Category shRNA
Disease name primary open-angle glaucoma (POAG)
Species Homo sapiens
Tissues/Cell_line primary human trabecular meshwork cells
Methods transduction, Western blot, immunofluorescence, transwell assay, CCK-8 assay, Ki67 staining, Edu assay
Expression pattern associated
Functional description HES1 shRNA abrogated the extracellular matrix protein up-regulation and rescued the functional defects caused by the oxidative stress.
PubMed ID 28423527
Year 2017
Title HES1 promotes extracellular matrix protein expression and inhibits proliferation and migration in human trabecular meshwork cells under oxidative stress.
Drug-related ncRNA NA

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