A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of primary open-angle glaucoma (POAG)
ncRNA name ENST00000607393
ncRNA Category lncRNA
Ensembl ENSG00000272043
Synonyms AC016405.2
Disease name primary open-angle glaucoma (POAG)
Species Homo sapiens
Tissues/Cell_line aqueous humor, iris and plasma; primary human trabecular meshwork (HTM) cells
Methods qPCR, microarray, fluorescence in situ hybridization (FISH), RNAi
Expression pattern up-regulated
Functional description qRT-PCR confirmed that T267384, ENST00000607393, and T342877 expression levels were significantly higher in the AH from a different cohort of POAG patients. ENST00000607393 was also significantly higher in the iris and plasma of POAG patients. Last, ENST00000607393 knockdown alleviated calcification of primary human trabecular meshwork cells in vitro.
PubMed ID 30677397
Year 2019
Title Potential Biomarkers for Primary Open-Angle Glaucoma Identified by Long Noncoding RNA Profiling in the Aqueous Humor.
Drug-related ncRNA NO

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