|primary open-angle glaucoma (POAG)
|Mutations in the optineurin (OPTN) gene, including E50K, which encodes an amino acid substitution, have been associated with primary open angle glaucoma (POAG). A total of 62 lncRNAs showed differential expression between the OPTN (E50K) transgenic mice and wild-type mice, which included 32 downregulated and 30 upregulated lncRNAs.
|Microarray expression profile analysis of long non-coding RNAs in optineurin E50K mutant transgenic mice
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