A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of optic nerve injury
ncRNA name rno-miR-21
ncRNA Category miRNA
Disease name optic nerve injury
Species Rattus norvegicus
Tissues/Cell_line optic nerves
Methods transfection, immunohistochemistry, Western blot, qRT-PCR, in situ hybridization
Expression pattern up-regulated
Functional description Inhibition of miR-21 regulates the EGFR pathway, ameliorating excessive astrocyte activation and glial scar progression and promoting axonal regeneration and alleviating impairment in F-VEP function in a model of ONC.
PubMed ID 29709341
Year 2018
Title Inhibition of miR-21 ameliorates excessive astrocyte activation and promotes axon regeneration following optic nerve crush.
Drug-related ncRNA NO

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