A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of optic nerve injury
ncRNA name dre-miR-29b
ncRNA Category miRNA
Disease name optic nerve injury
Species Danio rerio
Tissues/Cell_line retinas
Methods microarray, qRT-PCR, transfection, luciferase reporter assay
Expression pattern up-regulated
Functional description We focused on two over-expressed miRNAs (miR-29b and miR-223), and functionally validated seven of their predicted gene targets using RT-qPCR and luciferase assays to confirm miRNA-mRNA binding. Gene ontology analysis placed the miRNA-regulated genes in key biological processes that included cell survival/apoptosis, ECM-cytoskeleton signaling, and heparan sulfate proteoglycan binding.
PubMed ID 26265132
Year 2015
Title Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration.
Drug-related ncRNA NO

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