|optic nerve injury
|qRT-PCR, immunoblot, immunohistochemistry, luciferase reporter assay, transduction, siRNA transfection, flow cytometry
|miR-30b inhibits Sema3A expression. Decreased Sema3A expression promotes axon outgrowth in RGCs due to reduced levels of Sema3A binding to NRP1 and PlexA1 and simultaneously reduces apoptosis by inhibiting the p38MAPK and caspase-3 pathways.
|MicroRNA-30b promotes axon outgrowth of retinal ganglion cells by inhibiting Semaphorin3A expression.
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