A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of optic nerve injury
ncRNA name rno-miR-30b
ncRNA Category miRNA
Disease name optic nerve injury
Species Rattus norvegicus
Tissues/Cell_line retinas
Methods qRT-PCR, immunoblot, immunohistochemistry, luciferase reporter assay, transduction, siRNA transfection, flow cytometry
Expression pattern up-regulated
Functional description miR-30b inhibits Sema3A expression. Decreased Sema3A expression promotes axon outgrowth in RGCs due to reduced levels of Sema3A binding to NRP1 and PlexA1 and simultaneously reduces apoptosis by inhibiting the p38MAPK and caspase-3 pathways.
PubMed ID 25791621
Year 2015
Title MicroRNA-30b promotes axon outgrowth of retinal ganglion cells by inhibiting Semaphorin3A expression.
Drug-related ncRNA NO

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