A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of optic nerve injury
ncRNA name CASP2 siRNA
ncRNA Category siRNA
Disease name optic nerve injury
Species Rattus norvegicus
Tissues/Cell_line retinas
Methods siRNA injection, in situ hybridization, qRT-PCR, Western blot, immunohistochemical analysis
Expression pattern associated
Functional description RGC apoptosis induced by optic nerve injury involves activation of caspase-2, and that synthetic siRNAs designed to inhibit expression of caspase-2 represent potential neuroprotective agents for intervention in human diseases involving RGC loss.
PubMed ID 21677688
Year 2011
Title Ocular neuroprotection by siRNA targeting caspase-2.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.