A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of optic nerve injury
ncRNA name RhoA shRNA
ncRNA Category shRNA
Disease name optic nerve injury
Species Rattus norvegicus
Tissues/Cell_line retinas, optic nerves
Methods Western blot, shRNA injection, histology and immunohistochemistry
Expression pattern associated
Functional description AAV-RhoA shRNA decreased RhoA expression levels and promoted neurite outgrowth in vitro. In the ONC model, AAV-RhoA shRNA by itself had only weak beneficial effects on RGC axon regeneration. However, when combined with AAV-CNTF, AAV-RhoA shRNA significantly improved the therapeutic effect of AAV-CNTF on axon regeneration by nearly two fold.
PubMed ID 28017835
Year 2017
Title AAV-mediated transfer of RhoA shRNA and CNTF promotes retinal ganglion cell survival and axon regeneration.
Drug-related ncRNA NA

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