A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of optic nerve injury
ncRNA name S1PR1 shRNA
ncRNA Category shRNA
Disease name optic nerve injury
Species Mus musculus
Tissues/Cell_line retinas, optic nerves
Methods shRNA knockdown, immunostaining, Western blot, qRT‐PCR
Expression pattern associated
Functional description Silencing S1PR1 with an adeno-associated virus serotype 2 (AAV2) containing a shRNA specific to S1PR1 (AAV2.shRNA-S1PR1) exacerbated the loss of RGCs induced by optic nerve crush.
PubMed ID 27309795
Year 2016
Title Sphingosine 1-phosphate receptor 1 is required for retinal ganglion cell survival after optic nerve trauma.
Drug-related ncRNA NA

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