|optic nerve injury
|retinas, optic nerves
|shRNA knockdown, immunostaining, Western blot, qRT‐PCR
|Silencing S1PR1 with an adeno-associated virus serotype 2 (AAV2) containing a shRNA specific to S1PR1 (AAV2.shRNA-S1PR1) exacerbated the loss of RGCs induced by optic nerve crush.
|Sphingosine 1-phosphate receptor 1 is required for retinal ganglion cell survival after optic nerve trauma.
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