|human RPE cell line ARPE-19
|immunocytochemistry, transfection, WST-1 assay, EdU proliferation assay, qPCR, Western blot
|Over-expression of miR-328 is a risk for myopia. miR-328 dose-dependently increased HOXA9 expression in ARPE-19 and mouse primary RPE cells. Based on the human, animal and cellular data, the transcription factor HOXA9 may promote the expression of pro-myopia genes and RPE proliferation, which eventually contribute to myopia development.
|HOXA9 is a novel myopia risk gene.
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