|RPE cell line ARPE-19
|transfection, qPCR, Western blot, MTT assay, transwell assay, scratch assay, luciferase reporter assay
|SNPs rs644242 and rs662702 had marginal significance (P = 0.063), and further analyses showed that these SNPs were associated with extreme myopia (≤ -11 D). The OR for extreme myopia was 2.1 (empiric P = 0.007) for the CC genotype at SNP rs662702 at the 3'UTR. SNP rs662702 was predicted to be located in the microRNA-328 binding site.
|A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese.
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