A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of myopia
ncRNA name hsa-miR-328
ncRNA Category miRNA
Disease name myopia
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19; human scleral fibroblast cells
Methods transfection, qRT-PCR, immunoblot, WST-1 cell proliferation assay, luciferase reporter assay, in situ hybridization
Expression pattern associated
Functional description Retinoic acid (RA) dose-dependently increased microRNA-328 expression and, in turn, suppressed PAX6 expression. Reduction of miR-328 and/or RA can be potential strategies for myopia prevention or treatment.
PubMed ID 22447870
Year 2012
Title MicroRNA-328 may influence myopia development by mediating the PAX6 gene.
Drug-related ncRNA NO

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