|human RPE cell line ARPE-19; human scleral fibroblast cells
|transfection, qRT-PCR, immunoblot, WST-1 cell proliferation assay, luciferase reporter assay, in situ hybridization
|Retinoic acid (RA) dose-dependently increased microRNA-328 expression and, in turn, suppressed PAX6 expression. Reduction of miR-328 and/or RA can be potential strategies for myopia prevention or treatment.
|MicroRNA-328 may influence myopia development by mediating the PAX6 gene.
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