A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of herpes simplex virus keratitis
ncRNA name MMP-9 shRNA
ncRNA Category shRNA
Disease name herpes simplex virus keratitis
Species Mus musculus
Tissues/Cell_line corneas
Methods shRNA knockdown, RT-PCR, qPCR, gelatin zymography, immunohistochemistry
Expression pattern associated
Functional description Delivery of the pshMMP-9 stopped angiogenesis and decreased the severity of herpetic keratitis. However, interferon-alpha (IFN-alpha) and IFN- beta induced by pshRNA might also contribute to inhibition of herpetic simplex keratitis (HSK) in the cornea.
PubMed ID 15989422
Year 2005
Title Blocking mouse MMP-9 production in tumor cells and mouse cornea by short hairpin (sh) RNA encoding plasmids.
Drug-related ncRNA NA

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