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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name VLK siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line trabecular meshwork tissues
Methods RT-PCR, siRNA transfection, immunofluorescence, immunoblot, Liquid chromatography-tandem mass spectrometry (LC-MS-MS)
Expression pattern associated
Functional description Downregulation of VLK expression in TM cells using siRNA decreased tyrosine phosphorylation (TyrP) of ECM proteins and focal adhesions, and induced changes in cell shape in association with reduced levels of actin stress fibers and phospho-paxillin.
PubMed ID 27591737
Year 2017
Title Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells.
Drug-related ncRNA NO

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