ncRNA name | VLK siRNA |
ncRNA Category | siRNA |
Disease name | glaucoma |
Species | Homo sapiens |
Tissues/Cell_line | trabecular meshwork tissues |
Methods | RT-PCR, siRNA transfection, immunofluorescence, immunoblot, Liquid chromatography-tandem mass spectrometry (LC-MS-MS) |
Expression pattern | associated |
Functional description | Downregulation of VLK expression in TM cells using siRNA decreased tyrosine phosphorylation (TyrP) of ECM proteins and focal adhesions, and induced changes in cell shape in association with reduced levels of actin stress fibers and phospho-paxillin. |
PubMed ID | 27591737 |
Year | 2017 |
Title | Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells. |
Drug-related ncRNA | NO |
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