A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name CTGF siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Oryctolagus cuniculus
Tissues/Cell_line primary tenon cells; rabbit eyes
Methods siRNA transfection, Viral transduction, Western blot, immunocytochemistry, immunohistochemistry
Expression pattern associated
Functional description Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results.
PubMed ID 26554857
Year 2016
Title Evaluation of Adenovirus-Mediated Down-Regulation of Connective Tissue Growth Factor on Postoperative Wound Healing After Experimental Glaucoma Surgery.
Drug-related ncRNA NO

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