A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name mmu-miR-149
ncRNA Category miRNA
Disease name glaucoma
Species Mus musculus
Tissues/Cell_line retinas
Methods H&E staining, TUNEL assay, transfection, luciferase reporter assay, qRT-PCR, Western blot, CCK-8 assay, Annexin V-FITC/PI assay
Expression pattern associated
Functional description The downregulation of miR-149 confers protection to RGCs by means of activating the PI3K/Akt signaling pathway via upregulation of BTC in mice with glaucoma.
PubMed ID 30183321
Year 2018
Title Downregulation of microRNA-149 in retinal ganglion cells suppresses apoptosis through activation of the PI3K/Akt signaling pathway in mice with glaucoma.
Drug-related ncRNA NO

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