A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name mmu-miR-211
ncRNA Category miRNA
Disease name glaucoma
Species Mus musculus
Tissues/Cell_line retinal ganglion cell line RGC-5
Methods cell viability assay, apoptosis assay, qRT-PCR, immunoblot, fluorescent in situ hybridization (FISH), immunofluorescence, luciferase reporter assay
Expression pattern up-regulated
Functional description Our findings show that miR-211 negatively modulates cell survival programs upon high pressure challenge by regulating Frs2 signaling, and they define roles for miR-211/Frs2 cascade in a regulatory feedback loop that mediates the pathogenesis of glaucoma.
PubMed ID 30131252
Year 2018
Title Intraocular miR-211 exacerbates pressure-induced cell death in retinal ganglion cells via direct repression of FRS2 signaling.
Drug-related ncRNA NO

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