A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name Hic-5 siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line trabecular meshwork cells
Methods siRNA transfection, transduction, immunohistochemistry, immunofluorescence staining, immunoblot
Expression pattern associated
Functional description While recombinant Hic-5 induced actin stress fibers, FAs, αv integrin redistribution to the FAs, increased levels of αSMA, collagen-1, and myocilin, Hic-5 siRNA suppressed most of these responses in HTM cells. Hic-5 siRNA also suppressed TGF-β2-induced fibrogenic activity and dexamethasone-induced myocilin expression in HTM cells.
PubMed ID 26313302
Year 2015
Title Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells.
Drug-related ncRNA NO

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