| ncRNA name | Hic-5 siRNA |
| ncRNA Category | siRNA |
| Disease name | glaucoma |
| Species | Homo sapiens |
| Tissues/Cell_line | trabecular meshwork cells |
| Methods | siRNA transfection, transduction, immunohistochemistry, immunofluorescence staining, immunoblot |
| Expression pattern | associated |
| Functional description | While recombinant Hic-5 induced actin stress fibers, FAs, αv integrin redistribution to the FAs, increased levels of αSMA, collagen-1, and myocilin, Hic-5 siRNA suppressed most of these responses in HTM cells. Hic-5 siRNA also suppressed TGF-β2-induced fibrogenic activity and dexamethasone-induced myocilin expression in HTM cells. |
| PubMed ID | 26313302 |
| Year | 2015 |
| Title | Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells. |
| Drug-related ncRNA | NO |
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