A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name hsa-miR-26a
ncRNA Category miRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line scar samples and subconjunctival Tenon’s capsule tissues
Methods qRT-PCR, cell migration assay, luciferase reporter assay, Western blot
Expression pattern associated
Functional description It was found that miR-26a was significantly down-regulated in filtering tract scar.The key finding of the current study is that miR-26a can suppress the activation of HTFs by transforming growth factor (TGF)-β by targeting CTGF. This data indicates that miR-26a plays an essential role in the formation of filtering tract scar and function as a potential drug target.
PubMed ID 28685590
Year 2018
Title A key role of microRNA-26a in the scar formation after glaucoma filtration surgery.
Drug-related ncRNA NO

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