| ncRNA name | hsa-miR-143 |
| ncRNA Category | miRNA |
| Disease name | glaucoma |
| Species | Homo sapiens |
| Tissues/Cell_line | human trabecular meshwork (HTM) cells; human aortic smooth muscle cells (HASMC); human choroidal endothelial cells (HCEC); human RPE cell line ARPE-19 |
| Methods | transfection, phalloidin staining, qRT-PCR, luciferase reporter assay |
| Expression pattern | up-regulated |
| Functional description | Targeted deletion of miR-143/145 in mice results in significantly reduced IOP, consistent with an ~2-fold increase in outflow facilities.We found that miR-143/145 regulates actin dynamics and the contractility of TM cells, consistent with its regulation of actin-related protein complex (ARPC) subunit 2, 3, and 5, as well as myosin light chain kinase (MLCK) in these cells. |
| PubMed ID | 28424493 |
| Year | 2017 |
| Title | Regulation of intraocular pressure by microRNA cluster miR-143/145. |
| Drug-related ncRNA | NO |
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