A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name hsa-miR-143
ncRNA Category miRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human trabecular meshwork (HTM) cells; human aortic smooth muscle cells (HASMC); human choroidal endothelial cells (HCEC); human RPE cell line ARPE-19
Methods transfection, phalloidin staining, qRT-PCR, luciferase reporter assay
Expression pattern up-regulated
Functional description Targeted deletion of miR-143/145 in mice results in significantly reduced IOP, consistent with an ~2-fold increase in outflow facilities.We found that miR-143/145 regulates actin dynamics and the contractility of TM cells, consistent with its regulation of actin-related protein complex (ARPC) subunit 2, 3, and 5, as well as myosin light chain kinase (MLCK) in these cells.
PubMed ID 28424493
Year 2017
Title Regulation of intraocular pressure by microRNA cluster miR-143/145.
Drug-related ncRNA NO

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