A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name ADAR2 siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Rattus norvegicus
Tissues/Cell_line retinal ganglion cells (RGCs)
Methods qRT-PCR, Western blot, immunohistochemistry, TUNEL assay, siRNA transfection, immunocytochemistry
Expression pattern associated
Functional description Knockdown of ADAR2 using siRNA increased the accumulation of Co(2+) in response to glutamate, and decreased the rectification index of AMPA currents detected electrophysiologically, indicating an increased Ca(2+) permeability through AMPARs.
PubMed ID 24608178
Year 2014
Title Down-regulation of the RNA editing enzyme ADAR2 contributes to RGC death in a mouse model of glaucoma.
Drug-related ncRNA NO

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