|retinal ganglion cells (RGCs)
|qRT-PCR, Western blot, immunohistochemistry, TUNEL assay, siRNA transfection, immunocytochemistry
|Knockdown of ADAR2 using siRNA increased the accumulation of Co(2+) in response to glutamate, and decreased the rectification index of AMPA currents detected electrophysiologically, indicating an increased Ca(2+) permeability through AMPARs.
|Down-regulation of the RNA editing enzyme ADAR2 contributes to RGC death in a mouse model of glaucoma.
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