A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name SYL040012
ncRNA Category siRNA
Disease name glaucoma
Species Oryctolagus cuniculus
Tissues/Cell_line ciliary bodies, lachrymal glands, corneas; rabbit fibroblast cell line RAB-9
Methods siRNA transfection, qPCR, MTT assay
Expression pattern associated
Functional description SYL040012 reduces IOP in normotensive and hypertensive animal models and the effect appears to be long lasting and extremely well tolerated both locally and systemically.
PubMed ID 24025749
Year 2014
Title In vitro and in vivo efficacy of SYL040012, a novel siRNA compound for treatment of glaucoma.
Drug-related ncRNA NO

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