ncRNA name | hsa-miR-483-3p |
ncRNA Category | miRNA |
Disease name | glaucoma |
Species | Homo sapiens |
Tissues/Cell_line | human trabecular meshwork cells (HTMCs) |
Methods | qRT-PCR, luciferase reporter assay, Western blot, immunofluorescence |
Expression pattern | down-regulated |
Functional description | MicroRNA-483-3p has an inhibitory effect on ECM production in HTMCs through downregulating Smad4, which indicates that miR-483-3p may serve as a potential therapeutic target in glaucoma. |
PubMed ID | 26747772 |
Year | 2015 |
Title | MicroRNA-483-3p Inhibits Extracellular Matrix Production by Targeting Smad4 in Human Trabecular Meshwork Cells. |
Drug-related ncRNA | NO |
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