A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name hsa-miR-483-3p
ncRNA Category miRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human trabecular meshwork cells (HTMCs)
Methods qRT-PCR, luciferase reporter assay, Western blot, immunofluorescence
Expression pattern down-regulated
Functional description MicroRNA-483-3p has an inhibitory effect on ECM production in HTMCs through downregulating Smad4, which indicates that miR-483-3p may serve as a potential therapeutic target in glaucoma.
PubMed ID 26747772
Year 2015
Title MicroRNA-483-3p Inhibits Extracellular Matrix Production by Targeting Smad4 in Human Trabecular Meshwork Cells.
Drug-related ncRNA NO

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