| ncRNA name | RhoA siRNA |
| ncRNA Category | siRNA |
| Disease name | glaucoma |
| Species | Mus musculus |
| Tissues/Cell_line | mouse embryonic fibroblast cell line NIH3T3; TM tissues |
| Methods | siRNA transfection and injection, qPCR, Western blot, immunohistochemical and H&E staining |
| Expression pattern | associated |
| Functional description | (1) siRNA injection into the anterior chamber leads to transient gene transfection in TM; (2) inhibiting RhoA expression in TM with siRNA is effective in suppressing elevated IOP in mice, suggesting that siRhoA is a potential pharmaceutical intervention for glaucoma. |
| PubMed ID | 22741561 |
| Year | 2012 |
| Title | siRNA silencing of gene expression in trabecular meshwork: RhoA siRNA reduces IOP in mice. |
| Drug-related ncRNA | NO |
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