A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name RhoA siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Mus musculus
Tissues/Cell_line mouse embryonic fibroblast cell line NIH3T3; TM tissues
Methods siRNA transfection and injection, qPCR, Western blot, immunohistochemical and H&E staining
Expression pattern associated
Functional description (1) siRNA injection into the anterior chamber leads to transient gene transfection in TM; (2) inhibiting RhoA expression in TM with siRNA is effective in suppressing elevated IOP in mice, suggesting that siRhoA is a potential pharmaceutical intervention for glaucoma.
PubMed ID 22741561
Year 2012
Title siRNA silencing of gene expression in trabecular meshwork: RhoA siRNA reduces IOP in mice.
Drug-related ncRNA NO

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