A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name RhoA siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human trabecular meshwork cells (HTMCs)
Methods siRNA transfection, qPCR, Western blot
Expression pattern associated
Functional description (1) siRNA injection into the anterior chamber leads to transient gene transfection in TM; (2) inhibiting RhoA expression in TM with siRNA is effective in suppressing elevated IOP in mice, suggesting that siRhoA is a potential pharmaceutical intervention for glaucoma.
PubMed ID 22741561
Year 2012
Title siRNA silencing of gene expression in trabecular meshwork: RhoA siRNA reduces IOP in mice.
Drug-related ncRNA NO

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