|human trabecular meshwork cells (HTMCs)
|siRNA transfection, qPCR, Western blot
|(1) siRNA injection into the anterior chamber leads to transient gene transfection in TM; (2) inhibiting RhoA expression in TM with siRNA is effective in suppressing elevated IOP in mice, suggesting that siRhoA is a potential pharmaceutical intervention for glaucoma.
|siRNA silencing of gene expression in trabecular meshwork: RhoA siRNA reduces IOP in mice.
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