A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name P2Y(2) siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Oryctolagus cuniculus
Tissues/Cell_line ciliary process samples
Methods siRNA instillation, RT-PCR, qPCR, Western blot, immunohistochemistry
Expression pattern associated
Functional description P2Y(2) receptors increase IOP in New Zealand rabbits. The application of a siRNA for this receptor significantly reduced IOP, suggesting that this technology might be used for the treatment of glaucoma.
PubMed ID 21740413
Year 2012
Title Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits.
Drug-related ncRNA NO

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