| ncRNA name | Smad3 siRNA |
| ncRNA Category | siRNA |
| Disease name | glaucoma |
| Species | Homo sapiens |
| Tissues/Cell_line | human optic nerve head astrocytes and lamina cribrosa cells |
| Methods | immunohistochemistry, Western blot, ELISA, siRNA transfection |
| Expression pattern | associated |
| Functional description | TGF-β2 utilizes the canonical Smad signaling pathway to stimulate ECM synthesis in human ONH cells. Knockdown of either Smad2 or Smad3 via small interfering RNA (siRNA) reduced TGF-β2 stimulated ECM proteins in ONH astrocytes and LC cells. |
| PubMed ID | 21738403 |
| Year | 2011 |
| Title | Transforming growth factor-β2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway. |
| Drug-related ncRNA | NO |
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