|human trabecular meshwork cells
|Western blot, immunohistochemistry, siRNA transfection
|TGM2 is a calcium-dependent enzyme that mediates cross-linking of ECM proteins, thus making ECM proteins resistant to enzymatic degradation and physical breakdown. TGF-β2 induction of TGM2 can be mediated via the canonical Smad-signaling pathway. SiRNA knockdown of Smad3 (p < 0.05) suppressed TGF-β2 induction of TGM2.
|Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells.
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