| ncRNA name | Smad3 siRNA |
| ncRNA Category | siRNA |
| Disease name | glaucoma |
| Species | Homo sapiens |
| Tissues/Cell_line | human trabecular meshwork cells |
| Methods | Western blot, immunohistochemistry, siRNA transfection |
| Expression pattern | associated |
| Functional description | TGM2 is a calcium-dependent enzyme that mediates cross-linking of ECM proteins, thus making ECM proteins resistant to enzymatic degradation and physical breakdown. TGF-β2 induction of TGM2 can be mediated via the canonical Smad-signaling pathway. SiRNA knockdown of Smad3 (p < 0.05) suppressed TGF-β2 induction of TGM2. |
| PubMed ID | 21722634 |
| Year | 2011 |
| Title | Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells. |
| Drug-related ncRNA | NO |
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