A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name Smad3 siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human trabecular meshwork cells
Methods Western blot, immunohistochemistry, siRNA transfection
Expression pattern associated
Functional description TGM2 is a calcium-dependent enzyme that mediates cross-linking of ECM proteins, thus making ECM proteins resistant to enzymatic degradation and physical breakdown. TGF-β2 induction of TGM2 can be mediated via the canonical Smad-signaling pathway. SiRNA knockdown of Smad3 (p < 0.05) suppressed TGF-β2 induction of TGM2.
PubMed ID 21722634
Year 2011
Title Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells.
Drug-related ncRNA NO

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