A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name TGFβR2 siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human optic nerve head astrocytes
Methods qRT-PCR, Western blot, siRNA transfection, immunofluorescence
Expression pattern associated
Functional description The authors investigated the role of myosin light chain kinase (MYLK) and transforming growth factor beta (TGFbeta) receptor pathways in optic nerve head (ONH) astrocyte migration. SiRNA directed against TGFbeta receptor 2 decreased cell migration compared with control and decreased extracellular matrix genes regulated by TGFbeta signaling.
PubMed ID 20375339
Year 2010
Title Modulation of factors affecting optic nerve head astrocyte migration.
Drug-related ncRNA NO

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