A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name Skp2 siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Oryctolagus cuniculus
Tissues/Cell_line rabbit Tenon's capsule fibroblast (rTF)
Methods siRNA transfection, immunocytochemistry, Western blot, MTT assay, BrdU incorporation assay
Expression pattern associated
Functional description Skp2 siRNA inhibited cell proliferation and decreased cell viability of rTF in vivo and in vitro. These findings suggest that siRNA-mediated gene silencing of Skp2 can be a novel gene therapy to treat scarring after glaucoma surgery by the suppression of p27(kip1) downregulation.
PubMed ID 19875654
Year 2010
Title Inhibition of cell proliferation of Tenon's capsule fibroblast by S-phase kinase-interacting protein 2 targeting SiRNA through increasing p27 protein level.
Drug-related ncRNA NO

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