| ncRNA name | Skp2 siRNA |
| ncRNA Category | siRNA |
| Disease name | glaucoma |
| Species | Oryctolagus cuniculus |
| Tissues/Cell_line | rabbit Tenon's capsule fibroblast (rTF) |
| Methods | siRNA transfection, immunocytochemistry, Western blot, MTT assay, BrdU incorporation assay |
| Expression pattern | associated |
| Functional description | Skp2 siRNA inhibited cell proliferation and decreased cell viability of rTF in vivo and in vitro. These findings suggest that siRNA-mediated gene silencing of Skp2 can be a novel gene therapy to treat scarring after glaucoma surgery by the suppression of p27(kip1) downregulation. |
| PubMed ID | 19875654 |
| Year | 2010 |
| Title | Inhibition of cell proliferation of Tenon's capsule fibroblast by S-phase kinase-interacting protein 2 targeting SiRNA through increasing p27 protein level. |
| Drug-related ncRNA | NO |
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