| ncRNA name | IKKB siRNA |
| ncRNA Category | siRNA |
| Disease name | glaucoma |
| Species | Homo sapiens |
| Tissues/Cell_line | human Tenon's capsule fibroblasts (HTFs) |
| Methods | siRNA transfection, qRT-PCR, Western blot, cell proliferation assay |
| Expression pattern | associated |
| Functional description | IKKB-siRNAs were successfully delivered into HTFs using CS-g-(PEI-b-mPEG) as a vector. As a result, the expression of IKKbeta was downregulated at both the mRNA and protein levels, and the activation of nuclear factor-kappaB (NF-kappaB) in the HTFs was subsequently inhibited. The proliferation of HTFs was also effectively suppressed through the blocking of the NF-kappaB pathway. |
| PubMed ID | 19137061 |
| Year | 2008 |
| Title | Cationic nano-copolymers mediated IKKbeta targeting siRNA inhibit the proliferation of human Tenon's capsule fibroblasts in vitro. |
| Drug-related ncRNA | NO |
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