A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name IKKB siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human Tenon's capsule fibroblasts (HTFs)
Methods siRNA transfection, qRT-PCR, Western blot, cell proliferation assay
Expression pattern associated
Functional description IKKB-siRNAs were successfully delivered into HTFs using CS-g-(PEI-b-mPEG) as a vector. As a result, the expression of IKKbeta was downregulated at both the mRNA and protein levels, and the activation of nuclear factor-kappaB (NF-kappaB) in the HTFs was subsequently inhibited. The proliferation of HTFs was also effectively suppressed through the blocking of the NF-kappaB pathway.
PubMed ID 19137061
Year 2008
Title Cationic nano-copolymers mediated IKKbeta targeting siRNA inhibit the proliferation of human Tenon's capsule fibroblasts in vitro.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.