|human Tenon's capsule fibroblasts (HTFs)
|siRNA transfection, qRT-PCR, Western blot, cell proliferation assay
|IKKB-siRNAs were successfully delivered into HTFs using CS-g-(PEI-b-mPEG) as a vector. As a result, the expression of IKKbeta was downregulated at both the mRNA and protein levels, and the activation of nuclear factor-kappaB (NF-kappaB) in the HTFs was subsequently inhibited. The proliferation of HTFs was also effectively suppressed through the blocking of the NF-kappaB pathway.
|Cationic nano-copolymers mediated IKKbeta targeting siRNA inhibit the proliferation of human Tenon's capsule fibroblasts in vitro.
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