A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name hsa-miR-204
ncRNA Category miRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human trabecular meshwork cells (HTM)
Methods microarray, immunoblot, transfection, luciferase reporter assay
Expression pattern associated
Functional description FOXC1 is implicated in the etiology of glaucoma because mutations in the gene are among the causes of Axenfeld-Rieger syndrome which is often accompanied by glaucoma. It was observed that miR-204 caused decreased expression of FOXC1 and the FOXC1 target genes CLOCK, PLEKHG5, ITGβ1, and MEIS2 in the TM cultures.
PubMed ID 23541832
Year 2013
Title FOXC1 in human trabecular meshwork cells is involved in regulatory pathway that includes miR-204, MEIS2, and ITGβ1.
Drug-related ncRNA NO

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