A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name MGP siRNA
ncRNA Category siRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line primary human trabecular meshwork cells
Methods Alizarin red staining, siRNA transfection, qPCR
Expression pattern associated
Functional description The increased activity of the calcification marker, ALP, in glaucomatous trabecular meshworks might be indicative of an undergoing mineralization process during development of the disease. Silencing MGP by siRNA resulted in ALP activity that was increased by 197% +/- 8.4% (P
PubMed ID 17591888
Year 2007
Title Presence of an established calcification marker in trabecular meshwork tissue of glaucoma donors.
Drug-related ncRNA NO

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