|primary human trabecular meshwork cells
|Alizarin red staining, siRNA transfection, qPCR
|The increased activity of the calcification marker, ALP, in glaucomatous trabecular meshworks might be indicative of an undergoing mineralization process during development of the disease. Silencing MGP by siRNA resulted in ALP activity that was increased by 197% +/- 8.4% (P = 0.0003).
|Presence of an established calcification marker in trabecular meshwork tissue of glaucoma donors.
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