A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name hsa-miR-29b
ncRNA Category miRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human Tenon's fibroblasts (HTFs)
Methods microarray, qRT-PCR, transfection, Western blot, MTT assay
Expression pattern down-regulated
Functional description miR-29b acted as a suppressor of type I collagen gene by repressing the PI3K/Akt/Sp1 pathway in HTFs. Overexpression of miR-29b protected subconjunctival tissues against collagen production and fibrosis.
PubMed ID 22297492
Year 2012
Title Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon's fibroblasts.
Drug-related ncRNA NO

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