ncRNA name | hsa-miR-29b |
ncRNA Category | miRNA |
Disease name | glaucoma |
Species | Homo sapiens |
Tissues/Cell_line | human Tenon's fibroblasts (HTFs) |
Methods | microarray, qRT-PCR, transfection, Western blot, MTT assay |
Expression pattern | down-regulated |
Functional description | miR-29b acted as a suppressor of type I collagen gene by repressing the PI3K/Akt/Sp1 pathway in HTFs. Overexpression of miR-29b protected subconjunctival tissues against collagen production and fibrosis. |
PubMed ID | 22297492 |
Year | 2012 |
Title | Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon's fibroblasts. |
Drug-related ncRNA | NO |
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