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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name hsa-miR-24
ncRNA Category miRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human trabecular meshwork cells (HTM)
Methods transfection, qPCR, microarray, Western blot
Expression pattern associated
Functional description Cyclic mechanical stress (CMS) leads to alterations of cellular functions in the trabecular meshwork (TM), including the up-regulation of transforming growth factor beta 1 (TGFβ1), that can potentially contribute to the pathogenesis of glaucoma. miR-24 might play an important role in modulating the induction of TGFβ1 mediated by CMS through direct targeting of FURIN.
PubMed ID 20945401
Year 2011
Title MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN.
Drug-related ncRNA NO

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