| ncRNA name | Ror2 shRNA |
| ncRNA Category | shRNA |
| Disease name | glaucoma |
| Species | Homo sapiens |
| Tissues/Cell_line | primary TM cell line |
| Methods | immunostaining, Western blot, degenerate PCR, qRT-PCR, shRNA knockdown |
| Expression pattern | associated |
| Functional description | DEX induces the upregulation of noncanonical Wnt ligand Wnt5a. Recombinant WNT5a protein induces CLAN formation through the noncanonical Wnt receptor ROR2/RhoA/ROCK signaling axis. Knocking-down Ror2, the receptor of noncanonical Wnt signaling, abolished the effects of DEX on the TM cells. |
| PubMed ID | 23963164 |
| Year | 2013 |
| Title | Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling. |
| Drug-related ncRNA | NA |
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