A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name Ror2 shRNA
ncRNA Category shRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line primary TM cell line
Methods immunostaining, Western blot, degenerate PCR, qRT-PCR, shRNA knockdown
Expression pattern associated
Functional description DEX induces the upregulation of noncanonical Wnt ligand Wnt5a. Recombinant WNT5a protein induces CLAN formation through the noncanonical Wnt receptor ROR2/RhoA/ROCK signaling axis. Knocking-down Ror2, the receptor of noncanonical Wnt signaling, abolished the effects of DEX on the TM cells.
PubMed ID 23963164
Year 2013
Title Dexamethasone induces cross-linked actin networks in trabecular meshwork cells through noncanonical wnt signaling.
Drug-related ncRNA NA

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