A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of glaucoma
ncRNA name VEGF shRNA
ncRNA Category shRNA
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line human Tenon's capsule fibroblasts (HTFs)
Methods shRNA knockdown, qRT-PCR, Western blot, proliferation assay
Expression pattern associated
Functional description Both mRNA and protein levels of VEGF were reduced by lentivirus-mediated VEGF-shRNA, and proliferation of HTF cells was inhibited. VEGF may be a suitable therapeutic target for reducing scar tissue formation in glaucoma patients after filtration surgery.
PubMed ID 28168047
Year 2017
Title Suppression of Human Tenon Fibroblast Cell Proliferation by Lentivirus-Mediated VEGF Small Hairpin RNA.
Drug-related ncRNA NA

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